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Updated: Jan 5, 2026

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BCL2L1 is associated with γ-globin gene expression.

Yan Dai1, Elmutaz M Shaikho1,2, Jessica Perez1

  • 1Department of Medicine, Boston University School of Medicine, Boston, MA.

Blood Advances
|October 25, 2019
PubMed
Summary

BCL2L1 protein is linked to fetal hemoglobin (HbF) gene activation. Inhibiting BCL2L1 reduces HbF expression, while overexpressing it increases fetal hemoglobin (HbF) levels in blood cells.

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