Invasive Fusarium solani infections in patients with acute leukemia

Two cases of disseminated hyalohyphomycosis due to Fusarium solani in patients with acute nonlymphocytic leukemia were studied. The clinical features in both patients included fever, fungemia, severe myalgias, disseminated ecthyma gangrenosum-like skin lesions, ocular symptoms, and a fatal outcome despite systemic administration of amphotericin B in the setting of profound, persistent granulocytopenia. In vitro studies showed the resistance of both F. solani isolates to amphotericin B, 5-fluorocytosine, and imidazoles. This investigation confirmed the emergence of F. solani infection in immunosuppressed hosts.