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Updated: Jan 5, 2026

Morphometric Analyses of Retinal Sections
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Computerized Morphometric Analysis of Eryptosis.

Sanu Susan Jacob1, Keerthana Prasad2, Pragna Rao3

  • 1Department of Physiology, Kasturba Medical College-Manipal, Manipal Academy of Higher Education, Manipal, India.

Frontiers in Physiology
|October 26, 2019
PubMed
Summary

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This summary is machine-generated.

Researchers developed a new automated method to detect eryptosis, the programmed death of red blood cells. This simple, sensitive technique quantifies eryptotic red blood cells morphometrically with minimal manual input.

Area of Science:

  • Hematology
  • Cell Biology
  • Biophysics

Background:

  • Eryptosis, or red blood cell suicidal death, involves cell shrinkage, vesiculation, and phosphatidylserine externalization.
  • Existing methods for detecting eryptosis are often complex or lack sensitivity.
  • A need exists for a simple, automated, and sensitive method to quantify eryptosis.

Purpose of the Study:

  • To design a simple, sensitive, and automated computerized approach for detecting eryptotic red blood cells.
  • To quantify the hallmark morphological characteristics of eryptosis in real-time.
  • To validate the developed method for applications in hematology and disease research.

Main Methods:

  • Red blood cells from healthy volunteers were subjected to normal Ringer and hyperosmotic stress (NaCl).
Keywords:
cell shrinkageeryptosishematologyimage analysismorphometryvesiculations

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  • Morphometric comparisons were performed on photomicrographs of stressed and unstressed red blood cells.
  • A novel software-based technique was developed to analyze morphological markers of eryptosis.

    • Main Results:

    • The automated method successfully detected and differentiated normal and eryptotic red blood cells based on structural variations.
    • Receiver operating characteristic curve analysis demonstrated high sensitivity, specificity, and discriminatory accuracy for the identified markers.
    • The software-based technique showed efficacy when validated with red blood cells in malaria.

    Conclusions:

    • The developed automated method provides a simple, sensitive, and real-time quantification of eryptosis.
    • This technique offers a new approach to study eryptosis induced by various stressors and diseases.
    • The software has potential wide applications in hematology laboratories, blood banks, and medical research.