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Related Experiment Video

Updated: Jan 5, 2026

Detecting Migration and Infiltration of Neutrophils in Mice
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Neutrophils in Psoriasis.

Chih-Chao Chiang1,2,3, Wei-Jen Cheng1,4,5, Michal Korinek6,7,8

  • 1Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Frontiers in Immunology
|October 26, 2019
PubMed
Summary
This summary is machine-generated.

Neutrophils, key innate immune cells, play a significant role in psoriasis pathogenesis. This review details their involvement in inflammation, oxidative stress, and immune responses in psoriatic skin lesions.

Keywords:
degranulationimmunityneutrophil extracellular trapsneutrophilspsoriasisrespiratory burst

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Area of Science:

  • Immunology
  • Dermatology
  • Pathophysiology

Background:

  • Neutrophils are the most abundant innate immune cells.
  • Their pathogenic roles are linked to chronic inflammation and autoimmune diseases like psoriasis.
  • Psoriasis affects ~2-3% of the global population, with neutrophils being a hallmark in skin lesions.

Purpose of the Study:

  • To review recent advances (up to 2019) in understanding neutrophil roles in psoriasis pathophysiology.
  • To explore the impact of neutrophil functions on psoriatic immunity.
  • To examine clinical relationships associated with neutrophil activity in psoriasis.

Main Methods:

  • Literature review of recent (up to 2019) scientific reports.
  • Analysis of studies focusing on neutrophil functions in psoriasis.
  • Synthesis of information on oxidative stress, degranulation, and NETs in psoriatic neutrophils.

Main Results:

  • Psoriatic neutrophils exhibit increased oxidative stress, release granular components, and form neutrophil extracellular traps (NETs).
  • These neutrophil activities are implicated in both the initiation and maintenance phases of psoriasis.
  • Neutrophil functions like respiratory burst and degranulation significantly impact psoriatic immunity.

Conclusions:

  • Neutrophils are critical players in the pathophysiology of psoriasis.
  • Understanding neutrophil behavior in psoriatic lesions offers insights into disease mechanisms.
  • Targeting neutrophil functions may present therapeutic strategies for psoriasis.