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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Biobehavioral Interactions Between Stress and Alcohol.

Marcus M Weera¹, Nicholas W Gilpin¹

¹Marcus M. Weera, Ph.D., is a postdoctoral fellow in the Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Nicholas W. Gilpin, Ph.D., is a professor in the Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Alcohol Research : Current Reviews

|October 26, 2019

Summary

Stress significantly impacts alcohol consumption by interacting with key biological systems. Targeting these stress pathways, like the hypothalamic pituitary adrenal axis, may offer new treatments for alcohol use disorder and related conditions.

Keywords:

alcohol animal models stress

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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

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Published on: February 6, 2019

Area of Science:

Neuroscience
Pharmacology
Addiction Medicine

Background:

Stress is a known factor influencing alcohol consumption.
Understanding the neurobiological mechanisms linking stress and alcohol is crucial for developing effective treatments.

Purpose of the Study:

To review the effects of stress on alcohol drinking.
To examine the interactions between biological stress systems and alcohol consumption.

Main Methods:

Review of existing literature on stress and alcohol.
Focus on specific biological systems: hypothalamic pituitary adrenal axis, corticotropin releasing factor, dynorphin, neuropeptide Y, and norepinephrine.

Main Results:

Animal models indicate that biological stress systems are closely linked to alcohol drinking behaviors.
These systems play a significant role in the neurobiology of alcohol use.

Conclusions:

Biological stress systems represent promising targets for pharmacological interventions.
Developing medications targeting these pathways could aid in treating alcohol use disorder and comorbid stress-related disorders.