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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

639
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

676
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
676
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Autoimmune pancreatitis: an update.

Ashish Khandelwal1, Dai Inoue2, Naoki Takahashi3

  • 1Department of Radiology, Mayo Clinic, 200 First St, Rochester, MN, 55902, USA.

Abdominal Radiology (New York)
|October 26, 2019
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis (AIP) is a steroid-responsive chronic pancreatitis. This review updates knowledge on AIP's clinical features, diagnosis, imaging, and treatment, crucial for differentiating it from pancreatic cancer.

Keywords:
Autoimmune pancreatitisIdiopathic duct-centric pancreatitisIgG4International consensus diagnostic criteriaLymphoplasmacytic sclerosing pancreatitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Radiology

Background:

  • Autoimmune pancreatitis (AIP) knowledge has advanced significantly.
  • Type 1 AIP is linked to IgG4-related systemic disease.
  • Type 2 AIP is a distinct subtype affecting younger patients.

Purpose of the Study:

  • To provide an updated review of autoimmune pancreatitis (AIP).
  • To cover clinical manifestations, diagnosis, imaging features, and treatment of AIP.

Main Methods:

  • Literature review of autoimmune pancreatitis (AIP).
  • Synthesis of current clinical, histopathological, and imaging findings.
  • Analysis of diagnostic criteria and treatment responses.

Main Results:

  • Type 1 AIP diagnosis involves clinical, histopathological, imaging, and extra-pancreatic findings, plus steroid response.
  • Distinguishing AIP from pancreatic cancer is critical due to similar presentations.
  • Type 2 AIP presents uniquely, often in younger individuals.

Conclusions:

  • Autoimmune pancreatitis (AIP) is a steroid-responsive chronic pancreatitis.
  • Distinct imaging features aid in AIP diagnosis.
  • Accurate differentiation from pancreatic cancer is essential for appropriate management.