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Hypouricemia: what the practicing rheumatologist should know about this condition
Carlos Pineda1, Carina Soto-Fajardo2, Jaime Mendoza2
1Division of Musculoskeletal and Rheumatic Disorders, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco 289, Col. Arenal de Guadalupe, Alcaldía Tlalpan, 14389, Mexico City, Mexico. carpineda@yahoo.com.
Clinical Rheumatology
|October 26, 2019
Summary
Hypouricemia, or low serum urate, can indicate underlying health issues. Rheumatologists should recognize hypouricemia as a biomarker requiring further investigation for accurate diagnosis and treatment.
Area of Science:
- Nephrology and Rheumatology
- Urate Metabolism and Transport
Background:
- Hypouricemia is defined as serum urate concentration below 2 mg/dL (119 μmol/L).
- Practicing rheumatologists often consult on urate metabolism disorders.
- Understanding hypouricemia is crucial for rheumatologists.
Purpose of the Study:
- To provide an updated overview of hypouricemia for practicing rheumatologists.
- To review the etiology and clinical significance of hypouricemia.
- To highlight the role of medications in causing hypouricemia.
Main Methods:
- A narrative review of human hypouricemia literature.
- Literature search from January 1950 to July 2018.
- Categorization of hypouricemia causes into decreased production and increased renal elimination.
Main Results:
- Etiologies include decreased urate production and increased renal excretion.
- Medications like allopurinol, febuxostat, probenecid, and losartan can cause hypouricemia.
- Hypouricemia is linked to various pathological and potentially harmful conditions.
Conclusions:
- Rheumatologists must recognize hypouricemia as a significant biomarker.
- Further clinical investigation is essential for accurate diagnosis and treatment of hypouricemia.
- Hypouricemia warrants a deeper clinical evaluation by specialists.
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