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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
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The pharmacokinetics of flavanones
Iveta Najmanová1, Marie Vopršalová2, Luciano Saso3
1Faculty of Pharmacy, Department of Biological and Medical Sciences, Charles University, Hradec Králové, Czech Republic.
Critical Reviews in Food Science and Nutrition
|October 26, 2019
Summary
Flavanones are rapidly metabolized in the body, with conjugates and phenolic metabolites being the primary circulating forms. Understanding flavanone pharmacokinetics is essential for investigating their health effects.
Area of Science:
- Nutritional Science
- Pharmacology
- Biochemistry
Background:
- Flavanones, abundant in citrus fruits, are of interest due to potential health benefits.
- Understanding their pharmacokinetic profile is crucial for substantiating health claims and elucidating mechanisms.
Purpose of the Study:
- To review the absorption, metabolism, distribution, and excretion of flavanones in the body.
- To explore potential kinetic interactions between flavanones and drugs.
Main Methods:
- Literature review of existing pharmacokinetic studies on flavanones.
- Analysis of metabolic pathways, including conjugation and colonic metabolism.
- Comparison of flavanone pharmacokinetics across different forms (aglycone vs. glycoside) and species.
Main Results:
- Parent flavanones are minimally present in plasma due to rapid metabolism into conjugates (sulfates and glucuronides).
- A significant portion of flavanones reaches the colon, where they are metabolized into absorbable phenolic compounds.
- The form of flavanone (aglycone/glycoside) and species significantly influence pharmacokinetic behavior.
Conclusions:
- Flavanone pharmacokinetics are characterized by extensive metabolism, with conjugates and phenolic metabolites being key.
- Achievable plasma concentrations and half-lives of flavanone metabolites are critical considerations for biological effect studies.
- Further research into flavanone metabolite pharmacokinetics is warranted for accurate health impact assessment.
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