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[Clinical Diagnosis and Treatment Recommendations for Immune Checkpoint Inhibitor-related Hematological Adverse

Junling Zhuang1, Jingting Zhao1, Xiaoxiao Guo2

  • 1Department of Hemotology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|October 26, 2019
PubMed

Immune checkpoint inhibitors are able to reactivate the immune system therefore enhance the anti-tumor effects. However, over-activated T cells may induce immune related adverse events (irAEs). Hematological irAEs are rarely reported, which mainly represent as mono-lineage cytopenia or pancytopenia, including autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), neutropenia and aplastic anemia, sometimes even lethal, such as hemophagocytic lymphohistiocytosis. The clinical manifestations of hematological irAEs will be summarized and recommendations of diagnosis and treatment are proposed.

Keywords:
CytopeniaImmune checkpoint inhibitorImmune-related adverse events

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