Association between ADAMTS7 polymorphism and carotid artery plaque vulnerability
Hao-Wen Li1,2,3, Mi Shen4, Pei-Yi Gao4,5
1China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital.
Medicine
|October 26, 2019
Summary
Specific ADAMTS7 gene variants, rs7173743 and rs3825807, are linked to increased risk of vulnerable carotid plaques. These genetic factors influence atherosclerotic plaque stability, a key factor in artery disease.
Area of Science:
- Genetics and Cardiovascular Disease
- Molecular Biology and Atherosclerosis
Background:
- Genome-wide association studies (GWAS) have linked ADAMTS7 gene polymorphisms to atherosclerosis.
- The specific association between ADAMTS7 variants and the stability of atherosclerotic plaques remains poorly understood.
Purpose of the Study:
- To investigate the relationship between two ADAMTS7 variants (rs3825807 and rs7173743) and the risk of ischemic stroke or vulnerable atherosclerotic plaques.
- To determine if these ADAMTS7 polymorphisms are associated with carotid plaque vulnerability.
Main Methods:
- Observational study including ischemic stroke patients and healthy controls.
- High-resolution magnetic resonance imaging (MRI) to classify carotid plaques as vulnerable or stable.
- Genotyping of ADAMTS7 single nucleotide polymorphisms (SNPs) rs3825807 and rs7173743 using TaqMan assays and real-time PCR.
- Multivariate logistic regression analysis to adjust for confounding risk factors.
Main Results:
- The study included 326 ischemic stroke patients and 432 controls.
- Both ADAMTS7 variants, rs7173743 and rs3825807, were significantly associated with carotid plaque vulnerability.
- No association was found between these variants and the overall prevalence of ischemic stroke.
- The T/T genotype of rs7173743 and the A/A genotype of rs3825807 were identified as risk genotypes for vulnerable plaque susceptibility.
Conclusions:
- ADAMTS7 genetic variants rs3825807 and rs7173743 are associated with an increased risk of developing vulnerable carotid plaques.
- These findings highlight the role of ADAMTS7 in atherosclerotic plaque instability, independent of ischemic stroke prevalence.
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