Related Experiment Video
Updated: Jan 5, 2026
05:37
An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
2.5K
Is it Worth CANVASing for CREDENCE? A Benefit-risk Analysis
1Department of Endocrinology, AMRI Hospitals, KB 24, KB Block, Sector III, Bidhannagar, Kolkata 700098, India.
Current Diabetes Reviews
|October 26, 2019
Summary
Canagliflozin shows benefits for heart failure and kidney outcomes, but amputation risks need careful consideration in pooled analyses. This analysis helps weigh the benefits against harms for canagliflozin use.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Endocrinology
Background:
- Canagliflozin use has presented mixed safety signals in major clinical trials.
- Conflicting data necessitates a clear understanding of the risk-benefit profile.
Purpose of the Study:
- To evaluate the risk-benefit ratio of canagliflozin using a Likelihood of being Helped or Harmed (LHH) analysis.
- To clarify the clinical implications of positive and negative safety signals from the CANVAS Program and CREDENCE trials.
Main Methods:
- Calculated LHH using Number Needed to Treat (NNT) and Number Needed to Harm (NNH) from trial data.
- Analyzed absolute risk reductions for key outcomes in CANVAS Program and CREDENCE trials.
Main Results:
- CANVAS: Canagliflozin showed benefit for MACE versus amputation, fractures, and euDKA; genital infections were more frequent. Heart failure benefits were offset by amputation and fracture risks.
- CREDENCE: LHH supported benefits for primary composite, renal composite, and MACE against adverse events.
- Pooled Data: Benefits for heart failure and renal composites were favored, but MACE benefits were outweighed by amputation risk.
Conclusions:
- Canagliflozin demonstrates favorable outcomes for heart failure and renal composites in individual and pooled analyses.
- Pooled analysis indicates that the benefits of canagliflozin for MACE are diminished by the risk of amputation.
More Related Videos
Related Concept Videos
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
367
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
367
01:31Confirmation Biases
7.6K
The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
7.6K
03:26Framing Effects
7.8K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.8K
01:23Methods of Documentation V: CBE
1.4K
Charting by Exception, or CBE, is a method of documentation used in healthcare, particularly in nursing, that focuses on documenting only significant or abnormal findings rather than recording every detail. This approach aims to streamline the documentation process, improve efficiency, and ensure that healthcare providers can quickly identify deviations from normalcy in patient assessments.
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
1.4K
01:52Persuasion Strategies
42.9K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
42.9K
02:30Naturalistic Observations
16.9K
If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
16.9K