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Updated: Jan 5, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
[Percutaneous treatment of mitral regurgitation]
C Delhomme1, N Tence1, N Karam2
1Département de cardiologie, hôpital européen Georges-Pompidou, AP-HP, Paris, France; Université Paris Descartes, Paris, France.
Insights
Severe mitral regurgitation (MR) affects many, with half denied surgery due to risks. Percutaneous edge-to-edge repair offers a vital alternative for high-risk patients, as reviewed in this article.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Mitral regurgitation (MR) is the most prevalent valvular heart disease and the second most operated valve in Europe.
- Approximately 50% of patients with severe MR are not candidates for surgery due to comorbidities or advanced age, despite poor prognosis.
Observation:
- Percutaneous treatments for MR, including repair and replacement, have emerged as alternatives for high-risk surgical patients.
- Percutaneous edge-to-edge repair is the predominant technique and is endorsed by European Guidelines for Valvular Heart Disease Management.
Findings:
- This review examines various MR repair strategies.
- It details the indications and evidence supporting these percutaneous interventions.
Implications:
- Percutaneous MR repair expands treatment options for patients previously denied surgical intervention.
- These minimally invasive techniques offer a viable solution for managing severe MR in high-risk populations.
- The review provides crucial insights into current evidence and guidelines for percutaneous MR repair.
Abstract:
Mitral regurgitation (MR) is currently the most frequent valvular heart disease, and the second most operated valve in Europe. Around 50% of patients presenting severe MR are denied surgery, despite the adverse prognosis associated with the absence of treatment, due to comorbidities and/or advanced age. During the previous years, percutaneous treatment of MR, whether by replacement or, more frequently, by repair, has been developed, providing an alternative for those patients who are deemed at prohibitive, but also, high surgical risk. Percutaneous edge-to-edge repair is currently the most frequently used technique, and is the only one recommended by the European Guidelines for Valvular Heart Disease Management. In the current article, we review the different strategies for MR repair, as well as the indications and level of evidence for their use.
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