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Updated: Jan 5, 2026

RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
Published on: July 22, 2014
A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes
1Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 vkick@ucla.edu.
Abstract:
Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.
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