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Related Concept Videos

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
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Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

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Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

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Mathematical modelling of cell migration.

George Butler1, Jonathan Rudge1, Philip R Dash1

  • 1School of Biological Sciences, University of Reading, Reading, U.K.

Essays in Biochemistry
|October 27, 2019
PubMed
Summary
This summary is machine-generated.

Mathematical modeling simplifies complex cell migration processes. This review explores suitable modeling approaches, like differential equations and agent-based models, for understanding cell movement and intracellular dynamics.

Keywords:
cell biologycell migrationcomputational models

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Area of Science:

  • Cell Biology
  • Systems Biology
  • Biophysics

Background:

  • Cell migration is a complex biological process involving numerous cellular components.
  • Understanding cell migration dynamics is crucial in various biological and medical fields.
  • Mathematical modeling offers a framework to dissect and analyze these complex systems.

Purpose of the Study:

  • To review the application of mathematical modeling in understanding cell migration.
  • To discuss suitable mathematical modeling approaches for different aspects of cell migration.
  • To highlight challenges and the necessity of experimental validation in cell migration modeling.

Main Methods:

  • Review of existing literature on mathematical modeling of cell migration.
  • Discussion of differential equation-based models and agent-based models.
  • Identification of software tools for implementing these models.

Main Results:

  • Mathematical modeling can address various scales of cell migration, from intracellular signaling to population dynamics.
  • Differential equations and agent-based models are effective for simulating cell migration.
  • The review provides examples and discusses software facilitating model application for non-mathematicians.

Conclusions:

  • Mathematical modeling is a powerful tool for elucidating complex cell migration behaviors.
  • Choosing the appropriate modeling technique depends on the specific aspect of cell migration being studied.
  • Effective cell migration modeling requires integration with rigorous experimental data for parameterization.