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Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Optimizing biodegradable nanoparticle size for tissue-specific delivery.

Hanna K Mandl¹, Elias Quijano², Hee Won Suh¹

¹Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|October 27, 2019

Summary

This summary is machine-generated.

Small poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) preferentially target lung and bone marrow, while larger NPs accumulate in the liver and spleen. NP size influences biodistribution and cellular uptake in vivo.

Keywords:

Biodegradable nanoparticles Biodistribution Nanomedicine Poly(lactic-co-glycolic acid) (PLGA)Size Targeting

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Area of Science:

Biomedical Engineering
Nanotechnology
Pharmacology

Background:

Nanoparticles (NPs) show potential for targeted drug delivery.
NP size is critical for biological activity, but quantitative biodistribution data is limited.
Poly(lactic-co-glycolic acid) (PLGA) NPs are biodegradable and suitable for drug delivery.

Purpose of the Study:

To quantitatively assess the effect of poly(lactic-co-glycolic acid) nanoparticle (PLGA NP) size on biodistribution and cellular uptake.
To engineer PLGA NPs of varying sizes using a microfluidic platform.
To investigate how NP diameter influences tissue and cellular distribution after systemic administration.

Main Methods:

Engineered fluorescent, biodegradable PLGA NPs in sizes ranging from 120-440nm via microfluidics.
Administered NPs systemically and analyzed tissue and cellular distribution.
Quantified NP uptake in bulk tissues (lung, liver, spleen, bone marrow) and specific cell populations (alveolar cells, hematopoietic stem and progenitor cells).

Main Results:

Small NPs (~120nm) showed enhanced uptake in lung and bone marrow.
Larger NPs were primarily sequestered in the liver and spleen.
Small NPs demonstrated improved access to specific alveolar and hematopoietic stem/progenitor cells.

Conclusions:

PLGA NP size is a critical determinant of in vivo biodistribution.
NP size can be manipulated to tune delivery to specific tissues and cellular targets.
Findings support the use of size-controlled PLGA NPs for targeted drug delivery applications.