Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

3.8K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
3.8K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

449
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
449
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

252
Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
252

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human <i>in vivo</i> assessment of ketamine binding of the serotonin transporter-follow up at a higher dose.

Frontiers in neuroscience·2025
Same author

Application of milk mid-infrared spectroscopy for prediction of energy balance and associated traits in Fleckvieh and Holstein Friesian dairy cows.

Animal : an international journal of animal bioscience·2025
Same author

Effects of gender-affirming hormone therapy on gray matter density, microstructure and monoamine oxidase A levels in transgender subjects.

NeuroImage·2024
Same author

Treatment of advanced BP-NETS with lanreotide autogel/depot vs placebo: the phase III SPINET study.

Endocrine-related cancer·2024
Same author

Synthesis and preclinical evaluation of BOLD-100 radiolabeled with ruthenium-97 and ruthenium-103.

Dalton transactions (Cambridge, England : 2003)·2024
Same author

Error mitigation enables PET radiomic cancer characterization on quantum computers.

European journal of nuclear medicine and molecular imaging·2023
Same journal

Enhanced pre-therapy dosimetry for SSTR PET: A head-to-head preclinical assessment of [<sup>89</sup>Zr]Zr-DFO-TOC and [<sup>89</sup>Zr]Zr-DFO-TATE.

Nuclear medicine and biology·2026
Same journal

Pharmacokinetics and dosimetry of radiolabeled FAP-targeting single-domain antibody 4AH29 in Göttingen minipigs.

Nuclear medicine and biology·2026
Same journal

Comparative intra-articular retention of [<sup>177</sup>Lu]Lu-MAA and <sup>90</sup>Y resin in a rat knee model.

Nuclear medicine and biology·2026
Same journal

Evaluating the tumour detection efficacy of [<sup>18</sup>F]Fluorthanatrace positron emission tomography in a metastatic lung cancer animal model.

Nuclear medicine and biology·2026
Same journal

Development of a pyrogallol-formaldehyde resin column for one-step pre-purification of <sup>68</sup>Ge/<sup>68</sup>Ga generator eluates: Enhanced [<sup>68</sup>Ga]Ga-DOTA-TATE radiolabeling yield by selective removal of tetravalent cationic impurities.

Nuclear medicine and biology·2026
Same journal

[<sup>68</sup>Ga]Ga-NOTA-ATH001 positron emission tomography as a general tool for non-invasive detection of platelet derived growth factor receptor beta in mesenchymal cells.

Nuclear medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

10.4K

Sex-differences in [68Ga]Ga-DOTANOC biodistribution.

A Leisser1, K Lukic1, M Nejabat1

  • 1Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Austria.

Nuclear Medicine and Biology
|October 27, 2019
PubMed
Summary
This summary is machine-generated.

Gender, diabetes, and age significantly impact [68Ga]Ga-DOTANOC uptake in patients. Medications like proton pump inhibitors (PPIs) and oral antidiabetics (OADs) showed less influence on radiopharmaceutical organ accumulation.

Keywords:
DiabetesGenderNETPETSSTR[(68)Ga]Ga-DOTANOC

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

812
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

18.7K

Related Experiment Videos

Last Updated: Jan 5, 2026

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the GaIII Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

10.4K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

812
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

18.7K

Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Imaging
  • Somatostatin Receptor Imaging

Background:

  • Factors influencing organ uptake of somatostatin receptor (SSTR)-targeting radiopharmaceuticals are not well understood.
  • Understanding these factors is crucial for accurate interpretation of PET/CT scans using agents like [68Ga]Ga-DOTANOC.

Purpose of the Study:

  • To investigate the influence of gender on [68Ga]Ga-DOTANOC uptake in various organs.
  • To assess the impact of other clinical factors, including diabetes, age, and medications (PPIs, OADs), on [68Ga]Ga-DOTANOC uptake.

Main Methods:

  • Retrospective analysis of 118 [68Ga]Ga-DOTANOC PET/CT scans.
  • Assessment of Standardized Uptake Values (SUVmax and SUVmean) in the stomach, liver, spleen, kidneys, adrenal glands, and pancreas.
  • Collection of clinical data including gender, age, diabetes status, and medication history (PPIs, OADs, SSAs).

Main Results:

  • Female patients exhibited significantly lower [68Ga]Ga-DOTANOC uptake in the stomach, liver, adrenal glands, and kidneys compared to males.
  • Diabetes and younger age (<50 years) were associated with significantly higher stomach uptake (SUVmax and SUVmean).
  • Proton pump inhibitors (PPIs) minimally affected liver uptake, while oral antidiabetics (OADs) increased uptake in the stomach, spleen, and adrenal glands.

Conclusions:

  • Gender, diabetes, and age are significant determinants of [68Ga]Ga-DOTANOC organ uptake.
  • The influence of ongoing medications like PPIs and OADs on radiopharmaceutical uptake is less pronounced.
  • These findings are important for the accurate interpretation of [68Ga]Ga-DOTANOC PET/CT imaging.