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Updated: Jan 5, 2026

Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Pyrrole-quinazoline derivative as an easily accessible turn-off optical chemosensor for Cu2+ and resultant Cu2+
Wan-Wan Wang1, Yuan Wang1, Wei-Na Wu1
1College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China.
Abstract:
A simple chemosensor, 6-(1H-pyrrol-2-yl)-5,6-dihydro-benzo[4,5]imidazo[1,2-c]quinazoline (1), was synthesized via simple nucleophilic addition reaction coupled with Schiff base condensation. The probe 1 is aggregation-induced emission-active and could be used as an on-off fluorescence sensor toward Cu2+ in H2O/CH3CN (99.5%, v/v) solution. Furthermore, the resultant Cu2+ complex selectively responded to pyrophosphate (PPi) among various anions based on fluorescent on-off signal. In addition, the probe could be used for detecting Cu2+ and PPi in HeLa cells.
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