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Circulating biomarkers of cell death
Kerstin Wimmer1, Monika Sachet1, Rudolf Oehler1
1Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 27, 2019
Summary
New cell death types like necroptosis, ferroptosis, and pyroptosis offer insights into diseases. Circulating biomarkers from these cell death pathways can indicate disease stage and treatment effectiveness.
Area of Science:
- Molecular Biology
- Pathology
- Biochemistry
Background:
- Cell death is implicated in numerous diseases.
- Historically, apoptosis and necrosis were the primary recognized cell death types.
- Recent discoveries include necroptosis, ferroptosis, and pyroptosis, revealing complex cell death mechanisms in disease.
Purpose of the Study:
- To review circulating biomarkers associated with distinct cell death pathways.
- To explore the molecular basis of these biomarkers.
- To correlate biomarker levels with disease stage, therapy response, and prognosis.
Main Methods:
- Literature review of cell death mechanisms.
- Analysis of molecular patterns released during different cell death types.
- Examination of studies correlating biomarkers with clinical outcomes.
Main Results:
- Different cell death pathways release unique molecular patterns.
- These released molecules can be detected in blood flow as circulating biomarkers.
- Biomarker levels show correlations with disease progression, treatment efficacy, and patient prognosis.
Conclusions:
- The study highlights the significance of diverse cell death pathways in disease.
- Circulating biomarkers offer a non-invasive window into cell death processes.
- These biomarkers hold potential for improved disease monitoring and patient management.
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