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Related Experiment Video

Updated: Jan 5, 2026

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

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Partial ALPPS versus complete ALPPS for staged hepatectomy.

Xukun Wu1, Jiawei Rao1, Xiaozhuan Zhou1

  • 1Department of Organ Transplantation, First Affiliated Hospital of Sun, Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou, 510080, China.

BMC Gastroenterology
|October 28, 2019
PubMed
Summary
This summary is machine-generated.

Partial Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) offers comparable liver regeneration to complete ALPPS but with significantly fewer complications. This variation may be a safer alternative for patients needing staged hepatectomy.

Keywords:
Complete ALPPSFuture liver remnantHepatectomyPartial ALPPS

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Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Liver Regeneration

Background:

  • Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) enhances liver regeneration for insufficient future liver remnant (FLR).
  • Complete ALPPS is linked to high morbidity and mortality.
  • Partial ALPPS is a modified approach to potentially reduce these risks.

Purpose of the Study:

  • To conduct a meta-analysis comparing outcomes between partial ALPPS and complete ALPPS.
  • To evaluate the efficacy and safety of partial ALPPS versus complete ALPPS.

Main Methods:

  • A systematic literature search of PubMed, Embase, and Cochrane Library databases was performed up to April 2019.
  • Four studies involving 124 patients were included and assessed using the Newcastle-Ottawa Scale (NOS).
  • Meta-analysis was used to compare FLR hypertrophy, interval between stages, postoperative complications, and mortality.

Main Results:

  • Future liver remnant (FLR) hypertrophy was comparable between partial and complete ALPPS (p=0.09).
  • The time interval between surgical stages did not differ significantly (p=0.57).
  • Partial ALPPS demonstrated a significantly lower postoperative complication rate (OR=0.38; p=0.03) and a trend towards lower mortality (18.9% vs 4.9%; p=0.12).

Conclusions:

  • Partial ALPPS achieves similar FLR hypertrophy and inter-stage interval compared to complete ALPPS.
  • Partial ALPPS is associated with a reduced rate of postoperative complications.
  • Further research is warranted to optimize patient selection and refine outcomes for both procedures.