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Related Concept Videos

Aggression01:47

Aggression

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Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
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Secondary Motives: Affiliation Motivation and Aggression Motivation01:21

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Affiliation motivation is the intrinsic desire to connect with others and belong to a social group, which plays a crucial role in forming and maintaining personal relationships. This type of motivation is essential for psychological well-being, as it provides individuals with a sense of community and support. An example of this is a student who joins a study group in order to feel a sense of connection. People with high affiliation motivation actively seek social approval, take satisfaction in...
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Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

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Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Bullying02:04

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A modern form of aggression is bullying. As you learn in your study of child development, socializing and playing with other children is beneficial for children’s psychological development. However, as you may have experienced as a child, not all play behavior has positive outcomes. Some children are aggressive and want to play roughly. Other children are selfish and do not want to share toys. One form of negative social interactions among children that has become a national concern is...
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Related Experiment Video

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The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
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Biomarkers in aggression.

Mirko Manchia1, Stefano Comai2, Martina Pinna3

  • 1Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.

Advances in Clinical Chemistry
|October 28, 2019
PubMed
Summary
This summary is machine-generated.

Developing accurate predictive models for aggression is crucial for effective interventions. This review explores biological markers, including genetics and neuroimaging, to improve aggression prediction and prevention strategies.

Keywords:
Drug-treatmentEpigeneticsGeneticsMetabolomicsNeuroimagingProteomicsViolence

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Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • Aggressive behavior is a major cause of premature death globally.
  • Current predictive models for aggression lack sufficient sensitivity and specificity for effective primary interventions.
  • Phenotypic heterogeneity of aggression has hindered reliable biomarker identification.

Purpose of the Study:

  • To review current evidence on neuroimaging, genetic, transcriptomic, neurochemical, and metabolomic biomarkers for aggression.
  • To discuss the integration of biological data into predictive models for aggression.
  • To explore how identified biomarkers can inform pharmacological and preventive strategies.

Main Methods:

  • Comprehensive literature review of neuroimaging studies on aggression.
  • Extensive review of genetic determinants, including genome-wide association studies (GWAS) and candidate gene studies.
  • Review of transcriptomic, neurochemical, and metabolomic data relevant to aggression.

Main Results:

  • Neuroimaging, genetic, transcriptomic, neurochemical, and metabolomic approaches show promise in identifying aggression-related biomarkers.
  • Bioinformatics approaches facilitate the integration of inter-species data and the development of predictive algorithms.
  • Research is advancing by focusing on homogenous aggression subtypes and large sample sizes.

Conclusions:

  • Biomarkers are essential for improving the accuracy and precision of aggression prediction models.
  • Integrating diverse biological data through bioinformatics can enhance predictive capabilities.
  • Identified biomarkers hold potential for developing novel pharmacological treatments and enhancing preventive strategies for aggression.