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Review: Ewing Sarcoma Predisposition.

Pablo Gargallo1, Yania Yáñez2, Antonio Juan3

  • 1Clinical and Translational Oncology Research Group, La Fe Hospital, Av. Fernando Abril Martorell 106 Postal Code, 46026, Valencia, Spain. gargallo_pabtat@gva.es.

Pathology Oncology Research : POR
|October 28, 2019
PubMed
Summary
This summary is machine-generated.

Ewing sarcoma predisposition is complex, influenced by genetics and environment. This review integrates evidence on susceptibility factors, proposing an approach to understand their combined impact on this rare bone and soft tissue cancer in young people.

Keywords:
Cancer predispositionEwing sarcomaGenetic susceptibilityPolymorphism

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Area of Science:

  • Pediatric Oncology
  • Cancer Genetics
  • Tumor Biology

Background:

  • Ewing sarcoma is a rare bone and soft tissue tumor predominantly affecting children and teenagers.
  • The disease is characterized by specific chromosomal translocations, commonly involving the EWS and FLI1 genes.
  • Understanding Ewing sarcoma predisposition is limited, with ongoing research into environmental factors, ethnicity, and genetic polymorphisms.

Purpose of the Study:

  • To comprehensively review existing evidence on predisposing factors contributing to Ewing sarcoma susceptibility.
  • To examine the role of environmental influences, ethnicity, and genetic variations in Ewing sarcoma development.
  • To explore the prevalence of Ewing sarcoma within known cancer predisposition syndromes.

Main Methods:

  • Systematic review of published literature on Ewing sarcoma predisposition.
  • Analysis of studies investigating environmental factors, ethnicity, and genetic polymorphisms related to susceptibility.
  • Evaluation of the association between Ewing sarcoma and established cancer predisposition syndromes.

Main Results:

  • Identified various environmental factors, ethnic variations, and specific genetic polymorphisms potentially influencing Ewing sarcoma risk.
  • Highlighted the importance of studying these factors in conjunction with known cancer predisposition syndromes.
  • Synthesized current knowledge on the multifactorial nature of Ewing sarcoma susceptibility.

Conclusions:

  • Ewing sarcoma predisposition is influenced by a complex interplay of genetic and environmental elements.
  • An integrated approach considering multiple factors is crucial for a comprehensive understanding of Ewing sarcoma susceptibility.
  • Further research is warranted to elucidate the precise mechanisms underlying these predisposing factors.