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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Related Experiment Video

Updated: Jan 5, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Efficacy of a Device-Based Continuous Optimization Algorithm for Patients With Cardiac Resynchronization Therapy.

Nobuhiko Ueda1,2, Takashi Noda1, Kohei Ishibashi1

  • 1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center.

Circulation Journal : Official Journal of the Japanese Circulation Society
|October 29, 2019
PubMed
Summary
This summary is machine-generated.

The adaptive CRT algorithm improves outcomes for patients receiving cardiac resynchronization therapy, particularly those with mildly wide QRS or non-left bundle branch block. This new algorithm significantly reduces cardiac death and heart failure hospitalizations.

Keywords:
Adaptive cardiac resynchronization therapyAlgorithmsHeart failureMildly wide QRSNon-left bundle branch block

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Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) efficacy is limited in patients with mildly wide QRS or non-left bundle branch block (non-LBBB).
  • An adaptive CRT (aCRT) algorithm optimizes CRT performance.
  • This study evaluated the aCRT algorithm's impact in specific patient subgroups.

Purpose of the Study:

  • To assess the clinical effectiveness of the adaptive CRT (aCRT) algorithm.
  • To determine if aCRT improves outcomes in CRT patients with mildly wide QRS (120-149 ms) or non-LBBB.
  • To compare clinical outcomes between adaptive and non-adaptive CRT groups.

Main Methods:

  • A cohort of 104 CRT patients was divided into adaptive (n=48) and non-adaptive (n=56) groups.
  • The primary endpoint was a composite of cardiac death and/or heart failure hospitalization.
  • Kaplan-Meier and multivariate analyses were used to evaluate outcomes over a median follow-up of 700 days.

Main Results:

  • The aCRT algorithm significantly reduced the composite clinical outcome (log-rank P=0.0030).
  • This benefit was observed even in patients with mildly wide QRS (log-rank P=0.0077) and non-LBBB.
  • aCRT use was an independent predictor of better clinical outcomes (HR 0.28, P=0.015), including in mildly wide QRS patients (HR 0.12, P=0.015).

Conclusions:

  • The adaptive CRT (aCRT) algorithm is effective in improving clinical outcomes for CRT patients.
  • aCRT demonstrates significant benefits, reducing cardiac death and heart failure hospitalizations, even in challenging patient subgroups like those with mildly wide QRS.
  • The study supports the use of aCRT for optimizing CRT device performance and patient management.