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Related Concept Videos

Psychosis and Antipsychotic Drugs: Overview01:28

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
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Psychosis: Goals of Pharmacotherapy01:26

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Mania and Antimanic Drugs: Overview01:24

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Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
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Antipsychotic Drugs: Typical and Atypical Agents01:21

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Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
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Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
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Steroid-induced psychosis.

Michael Janes1, Shaw Kuster1, Tove M Goldson1

  • 1Department of Family and Community Medicine, Baylor Scott & White Health and Texas A&M Health Science Center College of MedicineTempleTexas.

Proceedings (Baylor University. Medical Center)
|October 29, 2019
PubMed
Summary
This summary is machine-generated.

Steroid-induced psychosis can occur even after local steroid injections, not just oral treatments. This case highlights a brief psychotic episode in a patient following a dexamethasone scrotal injection for pain management.

Keywords:
DSM-5Dexamethasonepsychotic episodesteroid treatmentsteroid-induced psychosis

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Steroid-induced psychosis is a recognized adverse effect of corticosteroid therapy.
  • While typically associated with oral or systemic administration, local steroid injections have also been implicated.

Observation:

  • A 35-year-old male with no prior psychiatric history experienced a brief psychotic episode.
  • The episode occurred the day after receiving a 5 mg dexamethasone injection into his scrotum.

Findings:

  • This case demonstrates that even a single, localized injection of a corticosteroid can precipitate psychosis.
  • The patient's psychosis resolved following the event, suggesting a transient effect.

Implications:

  • Clinicians should consider the potential for psychiatric side effects with local corticosteroid injections.
  • Further investigation into the risk factors and mechanisms of steroid-induced psychosis from localized administration is warranted.