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Modifiable and non-modifiable risk factors in ischemic stroke: a meta-analysis

Qinyuan Cui1, Niyaz Ahmad Naikoo1

  • 1Xingping people's hospital, No.15 jincheng road, xingping city, shaanxi province. China, 713100.

African Health Sciences
|October 29, 2019
PubMed

Insights

This meta-analysis found that elevated triglyceride and glucose levels significantly increase the risk of ischemic stroke, particularly in Asian populations. Other factors like cholesterol and age showed no significant association.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Stroke is a complex disease influenced by various modifiable and non-modifiable risk factors.
  • Key factors include lipids (total cholesterol, triglycerides, HDL-C, LDL-C) and glucose, alongside non-modifiable factors like age.
  • Understanding these risk factors is crucial for developing effective ischemic stroke prevention strategies.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between lipid profiles, glucose levels, age, and ischemic stroke risk.
  • To identify significant predisposing factors for ischemic stroke, with a focus on the Asian population.

Main Methods:

  • A meta-analysis was performed on data available up to 2018.
  • Included studies assessed age, total cholesterol, triglycerides, HDL-C, LDL-C, and glucose levels in ischemic stroke patients and controls.
  • Heterogeneity analysis was conducted on the extracted data.

Main Results:

  • Meta-analysis indicated that triglyceride and glucose levels are significantly associated with ischemic stroke (p=0.007 and p=0.01, respectively).
  • Total cholesterol, HDL-C, LDL-C, and age were not significantly associated with ischemic stroke in this analysis (p>0.05).
  • Significant heterogeneity was observed across the studies (P<0.00, I2>96%).

Conclusions:

  • Triglyceride and glucose levels are identified as significant predisposing factors for ischemic stroke.
  • Findings are particularly relevant to the Asian population, highlighting specific risk factors for stroke prevention.
Abstract

Keywords:
Ischemic strokemeta-analysismodifiablenon-modifiablerisk factors

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