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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Microscopic colitis: diagnosis and management.

Tristan Townsend1, Fiona Campbell2, Paul O'Toole1

  • 1Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, UK.

Frontline Gastroenterology
|October 29, 2019
PubMed
Summary
This summary is machine-generated.

Microscopic colitis (MC) causes chronic watery diarrhea, especially in older adults. While not increasing cancer risk, budesonide is the only proven effective treatment for remission.

Keywords:
chronic diarrhoeacollagenous colitislymphocytic colitismicroscopic colitis

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Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Microscopic colitis (MC) is a frequent cause of chronic, non-bloody, watery diarrhea in elderly individuals.
  • Diagnosis relies on specific histological findings, with increased prevalence of bile acid malabsorption and autoimmune diseases like celiac disease.
  • Risk factors include NSAIDs, PPIs, SSRIs, and smoking, but MC does not elevate colorectal neoplasia or mortality risk.

Purpose of the Study:

  • To provide a practical overview of microscopic colitis for gastroenterologists.
  • To discuss the diagnosis, risk factors, and management of MC.
  • To highlight the efficacy of budesonide in MC treatment.

Main Methods:

  • Review of current literature and clinical practice guidelines for microscopic colitis.
  • Analysis of diagnostic criteria and histological findings.
  • Evaluation of treatment options, focusing on evidence from randomized-controlled trials.

Main Results:

  • MC is a benign condition impacting quality of life, with specific histological diagnostic markers.
  • Several factors increase MC risk, yet it does not correlate with increased cancer or mortality.
  • Budesonide is the sole medication demonstrated effective and safe for inducing and maintaining remission in MC.

Conclusions:

  • Microscopic colitis requires a practical management approach for gastroenterologists.
  • While not life-threatening, MC significantly affects patient quality of life.
  • Budesonide represents the gold standard treatment for achieving and sustaining remission in microscopic colitis.