Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

533
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
533
General Anesthesia: Overview01:24

General Anesthesia: Overview

527
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
527
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

853
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
853
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

652
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
652
Stages of General Anesthesia01:22

Stages of General Anesthesia

1.4K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving Immune Checkpoint Blockade Efficacy in Melanoma Brain Metastases through Myddosomal inhibition with Emavusertib.

Molecular cancer therapeutics·2026
Same author

Comparison of thoracic epidural anesthesia with an erector spinae plane infusion for post-esophagectomy analgesia: a pragmatic retrospective cohort study.

Journal of thoracic disease·2025
Same author

Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice.

Frontiers in pain research (Lausanne, Switzerland)·2025
Same author

A case for myoglobin-macromolecular rate theory applied to pseudo peroxidase kinetics.

PeerJ·2025
Same author

Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade.

Nature communications·2024
Same author

A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain.

Pain·2024

Related Experiment Video

Updated: Jan 5, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.2K

Anesthesia and postoperative pain control-multimodal anesthesia protocol.

Alisha Bhatia1, Asokumar Buvanendran1

  • 1Rush University Medical Center, Department of Anesthesiology, Chicago, Illinois, USA.

Journal of Spine Surgery (Hong Kong)
|October 29, 2019
PubMed
Summary
This summary is machine-generated.

Multimodal analgesia (MMA) optimizes pain relief by combining non-opioid and opioid medications, reducing opioid use and side effects. This approach enhances recovery after surgery and improves patient outcomes.

Keywords:
Multimodal analgesiaanesthesiaenhanced recovery after surgery (ERAS)minimally invasive spine surgerynarcotics consumptionpain control

More Related Videos

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
12:40

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia

Published on: September 28, 2022

2.1K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.8K

Related Experiment Videos

Last Updated: Jan 5, 2026

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
05:39

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia

Published on: May 26, 2023

2.2K
A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
12:40

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia

Published on: September 28, 2022

2.1K
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.8K

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Multimodal analgesia (MMA) combines therapies to manage pain effectively while minimizing side effects.
  • Optimizing non-opioid interventions and reserving opioids for breakthrough pain is key to MMA.
  • MMA is integral to enhanced recovery after surgery (ERAS) protocols for improved perioperative care.

Purpose of the Study:

  • To highlight the benefits of multimodal analgesia (MMA) in pain management.
  • To emphasize the role of MMA in reducing opioid consumption and adverse effects.
  • To discuss the integration of MMA into enhanced recovery after surgery (ERAS) protocols.

Main Methods:

  • Utilizing additive or synergistic combinations of analgesics.
  • Optimizing non-pharmacologic and pharmacologic non-opioid interventions.
  • Reserving opioid analgesics for breakthrough pain management.

Main Results:

  • Patients on MMA protocols demonstrate lower opioid consumption compared to traditional methods.
  • MMA contributes to minimizing side effects associated with high-dose single-agent analgesia.
  • Successful MMA implementation requires collaboration among caregivers and patients.

Conclusions:

  • Multimodal analgesia (MMA) is an effective strategy for achieving adequate pain relief with reduced opioid reliance.
  • MMA enhances patient recovery, potentially leading to faster discharge and better resource utilization.
  • The collaborative implementation of MMA is crucial for optimizing patient outcomes and health system benefits.