Simple Aggregation-Induced Emission-Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro
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Published on: July 17, 2012
Xueran Lin1, Junhao Zhao1, Wei Huang1
1Department of Chemistry, Jinan University, Guangzhou, 510632, China.
Abstract:
Multifunctional nanoparticles were simply synthesized by mixing a TICT+AIE featured molecule (TPAPP-CHO) with PBS solution. The fluorescent (FL) dots entered the cells via energy-related endocytosis and were located in lysosome emitting green FL. This indicated that the nanoparticles were dissociated in the lysosome. Moreover, the synthesized nanoparticles (NPs) demonstrate potent cytotoxicity against human U87 glioblastoma cells by inducing cell apoptosis via triggering intracellular ROS overproduction.
