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Updated: Jan 5, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
[Early prevention progress of contrast induced nephropathy]
Wentao Sang1,2, Kehui Yang1,2, Xiao Li2
1School of Medicine, Shandong University, Jinan 250012, Shandong, China.
Insights
Contrast induced nephropathy (CIN) is a significant cause of hospital-acquired renal failure. Early identification of high-risk factors and preventive strategies are crucial for managing this condition.
Area of Science:
- Nephrology
- Radiology
- Cardiology
Background:
- Contrast induced nephropathy (CIN) is a leading cause of hospital-acquired renal failure.
- CIN is linked to extended hospital stays, increased healthcare expenses, and adverse patient outcomes.
- Risk factors for CIN include advanced age and diabetes mellitus.
Purpose of the Study:
- To review the current understanding of CIN.
- To explore advancements in the early prevention of CIN.
- To offer guidance for CIN prevention and identify new research avenues.
Main Methods:
- Review of current literature on CIN.
- Analysis of high-risk factors associated with CIN.
- Examination of CIN pathogenesis and preventive measures.
Main Results:
- CIN is a growing concern due to increased use of contrast media in medical procedures.
- Effective preventive measures include hydration, judicious contrast media selection, and medication management.
- Further research is needed to refine CIN prevention strategies.
Conclusions:
- Early recognition of CIN risk factors is essential.
- A multi-faceted approach to prevention, including hydration and appropriate contrast media use, is recommended.
- Continued research into CIN pathogenesis and novel preventive strategies is warranted.
Objective:
Contrast induced nephropathy (CIN) is acute renal injury following administration of contrast media during angiographic or other medical procedures, which represents as the third cause of hospital-acquired renal failure. CIN is associated with prolonged hospital stay, increased health-care costs, and undesirable clinical outcome. The risk of CIN includes advanced age and diabetes mellitus. With the rapid development of iconography and the wide application of interventional techniques, the patients with CIN are increasing. The preventive measures of CIN include hydration, using appropriate contrast media, stopping nephrotoxic drugs, ischemic preconditioning, renal replacement therapy, and using appropriate drugs. In this paper, the current status and early prevention progress of CIN will be reviewed from three aspects of the high-risk factors, pathogenesis and prevention, aiming to provide guidance for the early prevention of CIN and explore new research directions.
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