Palmoplantar depigmentation in Macaca fascicularis following Blaschko linear pattern

Area of Science:

• Dermatology
• Genetics
• Primatology

Background:

• Hypomelanosis of Ito is a rare neurocutaneous syndrome.
• It is characterized by Blaschkoid patterns of hypopigmentation.
• Associated anomalies are frequently observed.

Observation:

• A male cynomolgus monkey (Macaca fascicularis) presented with hypomelanosis of Ito.
• The condition exhibited characteristic hypopigmentation streaks and swirls.
• Palmoplantar involvement and polythelia were noted in the affected primate.

Findings:

• The case confirmed the presentation of hypomelanosis of Ito in a non-human primate model.
• The observed anomalies included palmoplantar hyperkeratosis and supernumerary nipples (polythelia).
• The Blaschkoid pattern of hypopigmentation was consistent with human cases.

Implications:

• This case expands the understanding of hypomelanosis of Ito beyond human subjects.
• Cynomolgus monkeys may serve as a valuable model for studying neurocutaneous disorders.
• Further research can explore genetic underpinnings and therapeutic strategies for hypomelanosis of Ito.