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Chiral Discrimination by a Binuclear Pd Complex Sensor Using 31P{1H} NMR
Zhongxiang Chen1,2, Mingxue Yang1,2, Zhaofeng Sun1,2
1The Key Laboratory of Coal to Ethylene Glycol and Its Related Technology , Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou , Fujian 350002 , China.
Abstract:
An axially chiral binuclear μ-hydroxo Pd complex (BPHP) first served as an excellent chiral sensor for discriminating a variety of analytes including amino alcohol, amino amide, amino acid, mandelic acid, diol, diamine, and monoamine by 31P{1H} NMR. A detailed recognition mechanism was proposed based on the single crystal and mass spectrum of Pd-complexes. In general, BPHP sensor, through extracting the acidic hydrogen of an analyte by its Pd-OH group, forms stable diastereomeric complexes with two enantiomers of the analyte giving well distinguishable split 31P{1H} NMR signals for chiral discrimination.
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