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SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.

Luís F Ribeiro1,2, Ben Verpoort1,2, Julie Nys1,2

  • 1VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.

Plos Biology
|October 29, 2019
PubMed
Summary

The sorting receptor SorCS1 controls neurexin (Nrxn) surface levels in neurons. SorCS1 directs Nrxn trafficking to the axon, ensuring proper synapse development and function.

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