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Published on: December 3, 2019
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Caenorhabditis Elegans and Probiotics Interactions from a Prolongevity Perspective
Marianna Roselli1, Emily Schifano2, Barbara Guantario3
1Research Centre for Food and Nutrition, CREA (Council for Agricultural Research and Economics), 00178 Rome, Italy. marianna.roselli@crea.gov.it.
International Journal of Molecular Sciences
|October 30, 2019
Summary
Probiotics show potential for longevity by combating age-related inflammation and oxidative stress. Studies in the nematode Caenorhabditis elegans reveal probiotics modulate key pathways, offering insights into anti-aging mechanisms.
Area of Science:
- Microbiology and Gerontology
- Host-Microbe Interactions
- Aging Research
Background:
- Aging is associated with inflammaging, a low-grade inflammatory state.
- Probiotics offer potential prolongevity benefits through various mechanisms.
- Understanding probiotic anti-aging effects requires suitable model systems.
Purpose of the Study:
- To review the impact of probiotics on age-related parameters in Caenorhabditis elegans.
- To explore probiotic mechanisms influencing oxidative stress, immunity, and pathogen defense in aging.
- To assess C. elegans as a model for studying probiotic-mediated longevity.
Main Methods:
- Analysis of existing literature on probiotics and C. elegans aging.
- Focus on conserved molecular pathways like IIS and p38 MAPK.
- Evaluation of age-related parameters including oxidative stress and immune response.
Main Results:
- Several probiotic strains demonstrate anti-aging effects in C. elegans.
- Probiotics modulate key aging pathways, including insulin/IGF-1 (IIS) and p38 MAPK.
- Probiotics enhance protection against pathogens and reduce oxidative stress in nematodes.
Conclusions:
- C. elegans is a valuable model for elucidating probiotic anti-aging mechanisms.
- Probiotic supplementation can positively influence longevity and healthspan.
- Further research in C. elegans can illuminate host prolongevity strategies.
