Early clinicopathologic description of nodoparanodopathy in the 19th century
Stéphane Mathis1, Gwendal Le Masson2, Jean-Michel Vallat2
1From the Department of Neurology (S.M., G.L.M.), Nerve-Muscle Unit, CHU Bordeaux (Pellegrin University Hospital), Bordeaux, France; and Department of Neurology (J.-M.V.), National Reference Center for "Rare Peripheral Neuropathies", University Hospital, Limoges, France. stephane.mathis@chu-bordeaux.fr.
Abstract:
Nodoparanodopathy is a recent concept in the field of peripheral neuropathy, corresponding to peripheral nerve disorders stemming from an autoimmune attack directed and limited to the nodal region. This concept was identified using modern techniques of electrophysiology, immunology, and pathology (including electron microscopy). We present here what we believe to be the earlier well-documented case of nodoparanodopathy in the medical literature, based on an article written by Samuel Gilbert Webber (1838-1926) in 1884.
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