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Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip
Published on: February 16, 2024
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Cervical cancer and vaginal microbiota changes
1Department of Gynecology and Oncogynecology, Military Medical Academy, P.U.Todorov Blvd. Block No. 5, Entr. B, Fl. 25, 1404, Sofia, Bulgaria. stkovachev@abv.bg.
Archives of Microbiology
|October 30, 2019
Summary
Vaginal microbiota disturbances were found in 71.9% of women with early-stage cervical cancer. Bacterial vaginosis was the most common issue, suggesting a link between vaginal health and cervical carcinogenesis.
Area of Science:
- Gynecology
- Microbiology
- Oncology
Background:
- Vaginal microbiota alterations may influence cervical carcinogenesis.
- Cervical cancer development can also impact vaginal microbial composition.
Purpose of the Study:
- To investigate changes in vaginal microbiota among women diagnosed with FIGO Stage I cervical cancer.
Main Methods:
- A survey was conducted from 2014-2019 involving 32 women (aged 38-55) with FIGO Stage I cervical cancer.
- Vaginal DNA microbiological tests were performed to identify bacterial vaginosis, other infections, or normal microbiota.
Main Results:
- Vaginal microbiota disturbances were observed in 71.9% of the participants.
- Bacterial vaginosis was diagnosed in 46.9% of women, aerobic vaginitis in 12.5%, Trichomonas vaginalis in 3.1%, and Candida Albicans in 3.1%.
- Normal vaginal microbiota was found in 28.1% of the women.
Conclusions:
- Bacterial dysbiosis, including bacterial vaginosis and aerobic vaginitis, may be an HPV-dependent cofactor in cervical neoplasia development.
- Further research is needed to confirm the contribution of vaginal microbiota dysbiosis to HPV infection and cervical carcinogenesis.
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