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Age-related compositional and functional changes in micro-pig gut microbiome.

Mi Young Lim1, Eun-Ji Song1,2, Kyung Soo Kang3

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|October 30, 2019
PubMed
Summary

Aging alters the gut microbiome, decreasing beneficial bacteria and increasing Bacteroides in pigs. Maintaining a balanced microbiome may promote a younger gut age, with micro-pigs serving as a valuable model for human aging studies.

Keywords:
16S sequencingAgingGut microbiomeMicro-pig

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Area of Science:

  • Microbiology
  • Gerontology
  • Animal Models

Background:

  • Human gut microbiota composition changes with age, potentially influenced by diet.
  • Investigating aging's impact on the gut microbiome requires controlling for nutrient intake.

Purpose of the Study:

  • To examine age-related gut microbiome alterations in micro-pigs independent of dietary factors.
  • To identify specific microbial changes and functional associations with aging in a controlled environment.

Main Methods:

  • Analysis of gut microbiomes from 126 micro-pigs across a wide age range (newborn to 10 years).
  • Micro-pigs were maintained in a consistently controlled environment to isolate aging effects.

Main Results:

  • Gut microbiome diversity continuously changed with age.
  • Beneficial microbes (probiotics, short-chain fatty acid producers) decreased with age, while Bacteroides increased.
  • Bacteroides played a key role in regulating the abundance of other beneficial microbes.

Conclusions:

  • Age-specific beneficial gut microbe ratios may contribute to a younger gut microbiome age.
  • Micro-pigs offer a relevant model for studying the human gut microbiome and aging due to physiological similarities.