Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 4, 2026

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells
08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

9.3K

Developing a Multidisciplinary Approach for Engineering Stem Cell Organoids.

Marissa E Wechsler1,2, Mariya Shevchuk2,3, Nicholas A Peppas4,5,6,7,8

  • 1Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Annals of Biomedical Engineering
|October 30, 2019
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent advances in intraoral, buccal and sublingual drug delivery systems and technologies.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Stealth polymer coatings of reactive oxygen species scavenging nanoparticles for immune response mitigation.

Bioengineering & translational medicine·2026
Same author

Systematic design of polybasic nanogels: influence of hydrophobic monomers on tunable physicochemical and biological properties.

npj biomedical innovations·2026
Same author

Delivery of Nucleic Acids for Vascular Tissue Engineering Applications.

Regenerative engineering and translational medicine·2025
Same author

33 Unresolved Questions in Nanoscience and Nanotechnology.

ACS nano·2025
Same author

Rational Design of PEGylated Nanogels: Optimization of Degree of PEGylation and Development of a Novel Enzyme-Responsive Grafted Layer.

International journal of pharmaceutics·2025

Stem cell-derived organoids better model human physiology for disease research and drug discovery. Optimizing conditions for organoid formation is key to overcoming reproducibility and scale-up challenges in this promising field.

Area of Science:

  • Stem cell biology
  • Synthetic biology
  • Bioengineering
  • Biotechnology

Background:

  • Organoids are 3D cellular structures that better model human physiology than traditional methods.
  • Organoids offer promise for disease modeling, drug discovery, and regenerative medicine.
  • Challenges remain in organoid research, particularly regarding reproducibility and scalability.

Purpose of the Study:

  • To review the essential components for robust organoid development and formation.
  • To discuss strategies for creating a supportive environment for cellular self-assembly and organization.
  • To highlight specific organoid examples and future research potential.

Main Methods:

  • Identifying optimal cellular sources for organoid generation.
Keywords:
BiomaterialsBrainCardiacIntestineSelf-assemblyStem cells

More Related Videos

A High-Throughput Platform for Culture and 3D Imaging of Organoids
07:42

A High-Throughput Platform for Culture and 3D Imaging of Organoids

Published on: October 14, 2022

3.7K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.8K

Related Experiment Videos

Last Updated: Jan 4, 2026

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells
08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

9.3K
A High-Throughput Platform for Culture and 3D Imaging of Organoids
07:42

A High-Throughput Platform for Culture and 3D Imaging of Organoids

Published on: October 14, 2022

3.7K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.8K
  • Engineering biomimetic matrices to promote cell-cell and cell-matrix interactions.
  • Providing biochemical and biophysical cues that mimic the in vivo environment.

    • Main Results:

    • The abstract does not detail specific experimental results but reviews the necessary components and conditions for organoid formation.
    • It emphasizes the multidisciplinary approach required to address current challenges.
    • It highlights the potential of organoids in various biomedical applications.

    Conclusions:

    • Achieving reproducible and scalable organoid formation requires careful control over cellular sources, matrix engineering, and environmental cues.
    • Organoid technology holds significant promise for advancing disease modeling, drug discovery, and regenerative medicine.
    • Continued research and a multidisciplinary approach are crucial for realizing the full potential of organoids.