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Chemical Antibody Mimics Inhibit Cadherin-Mediated Cell-Cell Adhesion: A Promising Strategy for Cancer Therapy

Paulina X Medina Rangel1, Elena Moroni1, Franck Merlier1

  • 1Sorbonne Universités, Université de Technologie de Compiègne, UMR CNRS 7025, Enzyme and Cell Engineering Laboratory, Rue Roger Couttolenc, CS 60319, 60203, Compiègne, France.

Angewandte Chemie (International Ed. in English)
|October 30, 2019
PubMed
Summary

Molecularly imprinted polymer nanoparticles (MIP-NPs) targeting cadherin adhesion sites show superior efficacy over therapeutic antibodies in disrupting cancer cell aggregation and tumor growth. These novel anti-adhesives offer potential for cancer immunotherapy.

Keywords:
adherincancer therapycell adhesionmolecularly imprinted polymertherapeutic antibodies

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