Canadian Multiple Sclerosis Pregnancy Study (CANPREG-MS): Rationale and Methodology

Area of Science:

• Neurology
• Reproductive Health
• Epidemiology

Background:

• Multiple sclerosis (MS) is a leading cause of neurological disability in young adults.
• Early diagnosis and disease-modifying therapies are increasingly available for MS.
• Limited population data exists to guide reproductive decisions for women with MS.

Purpose of the Study:

• To establish a prospective, Canada-wide, population-based registry for women with MS.
• To collect data on women with MS who are pregnant or planning pregnancy.
• To support informed reproductive decision-making for individuals with MS.

Main Methods:

• A real-world, prospective, population-based registry design.
• Inclusion of women with MS irrespective of disease course, therapy, duration, or disability.
• Complex methodology requiring detailed understanding for clinical interpretation.

Main Results:

• This paper details the rationale and methodology for the registry.
• The registry is currently ongoing with over 100 participants.
• Future publications will present study findings as they emerge.

Conclusions:

• The registry is actively recruiting participants.
• The study is designed to generate significant future publications.
• This foundational paper serves as a reference for subsequent research findings.