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Fluoride redeposition and retention during bone turnover in lactating rats
J Nopakun1, M K Guo, H H Messer
1Department of Oral Biology, School of Dentistry, University of Minnesota, Minneapolis 55455.
Journal of Dental Research
|September 1, 1988
Summary
Lactating rats with calcium stress lost significant bone fluoride. Fluoride loss correlated with bone resorption, with minimal redeposition, indicating poor fluoride retention during calcium deficiency.
Area of Science:
- Skeletal Biology
- Mineral Metabolism
- Fluoride Toxicology
Background:
- Adult bone remodeling is crucial for mineral homeostasis.
- Fluoride incorporation into bone occurs during skeletal development.
- Lactation imposes significant calcium demands, potentially stressing skeletal reserves.
Purpose of the Study:
- To assess the adult skeleton's ability to retain fluoride (F) during calcium (Ca) stress in lactating rats.
- To investigate the relationship between bone resorption, fluoride loss, and calcium deposition during lactation.
Main Methods:
- Rats incorporated fluoride from weaning until 11 weeks of age.
- Lactating dams were subjected to either adequate or low calcium intake.
- Bone resorption was quantified using tritiated tetracycline (3H-TC) loss.
- Bone calcium and fluoride content changes were analyzed.
Main Results:
- Bone resorption varied significantly, from 16.5% in the humerus (adequate Ca) to 77.1% in vertebrae (low Ca).
- Fluoride loss from bone was directly proportional to the extent of bone resorption (3H-TC loss).
- Fluoride redeposition was minimal (0-31.4%) and correlated with low calcium deposition.
Conclusions:
- The adult skeleton's capacity to retain fluoride is compromised during calcium stress in lactation.
- Fluoride resorption from bone during periods of high demand is substantial.
- Limited fluoride redeposition suggests that calcium availability is a key factor in skeletal fluoride retention.