Comparison of meclofenamate sodium and hydrocortisone for controlling the postsurgical inflammatory response in rats

The effectiveness of meclofenamate sodium and hydrocortisone in alleviation of local postsurgical swelling and leukocytic infiltration was compared at two postsurgical intervals in 60 male Sprague-Dawley rats. Both drugs were effective at 24 hours after surgery. Ten doses of 2 mg meclofenamate sodium administered over a 5-day period were more effective in reducing leukocytic infiltration than six doses of 2 mg hydrocortisone administered over the same period. Neither the hydrocortisone nor the meclofenamate sodium at the dosage used adversely affected osteoid formation.