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Pharmacokinetics of epirubicin in man. Non-influence of alpha interferon
Medical Oncology and Tumor Pharmacotherapy
|January 1, 1988
Abstract:
The influence of alpha interferon on the plasma pharmacokinetics of epirubicin has been studied in five patients with bronchial cancer. The pharmacokinetic studies of epirubicin (100 mg m-2) were performed prior to and immediately after a 3 wk period with daily natural alpha interferon treatment (6 x 10(6) IU i.m.). None of the patients had been treated with antracyclines or interferon prior to entering the present study. The plasma pharmacokinetics of epirubicin were most adequately described by a three compartment open model both prior to and after the interferon treatment. The interferon treatment had no influence on the pharmacokinetics of epirubicin (AUC, Cmax, terminal half life).