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Updated: Jan 4, 2026

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
Published on: December 22, 2014
Studying the gut virome in the metagenomic era: challenges and perspectives
Sanzhima Garmaeva1, Trishla Sinha1, Alexander Kurilshikov1
1Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Abstract:
The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of human-gut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major component. Lastly, we discuss what can be learned from studies of bacteriophages in other ecosystems.
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