[Humanized Mouse Models as a Tool to Study Proinflammatory Cytokine Overexpression].

Area of Science:

• Biomedical research
• Immunology
• Genetics

Background:

• Proinflammatory cytokines, such as tumor necrosis factor (TNF), interleukin-1 beta (IL-1β), and IL-6, are implicated in severe pathologies including rheumatoid arthritis, psoriasis, and neurodegenerative diseases.
• Transgenic mouse models with controllable cytokine overexpression are vital for dissecting disease mechanisms.
• Humanized mouse models, which incorporate human cytokine genes, offer enhanced relevance for studying human-specific inflammatory processes and therapeutic targets.

Purpose of the Study:

• To review available humanized mouse models overexpressing key proinflammatory and inflammatory cytokines.
• To highlight the significance of these models in basic and clinical research for understanding disease pathogenesis and developing novel therapies.

Main Methods:

• Review of existing literature on humanized mouse models.
• Focus on models with overexpression of TNF, IL-1β, IL-6, IL-8, IL-17, and IL-32.
• Analysis of the utility of these models in studying molecular mechanisms and therapeutic interventions.

Main Results:

• Humanized mice provide a relevant platform for investigating the role of specific cytokines in disease.
• These models facilitate the study of cytokine function, gene polymorphisms, and the development of targeted therapies.
• A range of humanized models for key cytokines are available, supporting diverse research applications.

Conclusions:

• Humanized mouse models are indispensable tools for advancing our understanding of inflammatory diseases.
• Their application is critical for preclinical research, drug development, and personalized medicine approaches.
• Continued development and utilization of these models will accelerate progress in treating cytokine-mediated pathologies.