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A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.

Kathleen Kerr¹, Gayle Morse^2,3, Donald Graves⁴

¹Department of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada. k.kerr@utoronto.ca.

International Journal of Environmental Research and Public Health

|October 31, 2019

Summary

Gulf War illness affects many veterans. A detoxification intervention involving exercise and supplements showed potential for improving quality of life and reducing symptoms in a pilot study.

Keywords:

Gulf War illness Hubbard Veteran’s SF-36 chemical warfare agents detoxification exposome exposure nicotinic acid organophosphates pesticides sauna

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Area of Science:

Environmental Medicine
Toxicology
Rehabilitation Medicine

Background:

Gulf War illness (GWI) affects approximately 30% of US veterans from the 1990-1991 Persian Gulf War.
The exact cause of GWI remains uncertain, but toxic exposures like pesticides and chemical warfare agents are suspected.
Currently, no effective medical treatments exist for GWI.

Purpose of the Study:

To evaluate the feasibility and efficacy of a detoxification enhancement intervention for veterans with GWI.
To assess the safety and potential benefits of the Hubbard detoxification regimen in a GWI cohort.

Main Methods:

A randomized, waitlist-controlled pilot study was conducted with 32 ill Gulf War veterans.
Participants were assigned to either the intervention group (exercise, sauna, supplements) or a 4-week waitlist control.
Outcomes included feasibility (recruitment, retention, safety) and efficacy (quality of life, pain, fatigue, neuropsychological tests), with blinded scoring.

Main Results:

The Hubbard regimen was feasible and safe, with all participants completing the trial and 21 completing 3-month follow-up.
The intervention group showed a mean improvement of 6.9 points on the SF-36 physical component summary score compared to the waitlist control.
11 out of 16 measures of quality of life, pain, and fatigue improved, with most benefits retained at 3 months.

Conclusions:

The Hubbard detoxification regimen is a feasible and safe intervention for veterans suffering from Gulf War illness.
This intervention may offer significant relief for GWI symptoms, including improvements in quality of life, pain, and fatigue.
Further research is warranted to confirm these findings in larger cohorts and explore long-term effects.