Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
Stem Cell Culture01:17

Stem Cell Culture

6.0K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.3K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.3K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

27.2K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.2K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.6K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian inference of haematopoietic stem/progenitor cell differentiation phenotypic manifolds and their bifurcation points using Gaussian processes and Gibbs sampling.

Scientific reports·2026
Same author

Translational human and equine regenerative medicine in musculoskeletal conditions.

Journal of equine veterinary science·2026
Same author

Right of reply - Response to: In defence of South Africa's National Health Research Ethics Council guidelines on heritable human genome editing.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Progress in advanced cellular and gene therapies in South Africa and barriers to patient access: A National Consortium paper on behalf of the BloodSA Cell and Gene Therapy working party.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

A possible genetic predisposition to suspected hypoxic-ischaemic encephalopathy.

Biochimica et biophysica acta. Molecular basis of disease·2025
Same journal

SAMA Health Summit Abstracts.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.1K

Stem cell therapy for neurological disorders.

M Alessandrini1, O Preynat-Seauve, K De Bruin

  • 1Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland. Marco.alessandrini@unige.ch.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|October 31, 2019
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers potential for neurological diseases, but more rigorous clinical trials are needed. Research is exploring neural, hematopoietic, and mesenchymal stem cells for conditions like MS, stroke, and spinal cord injuries.

More Related Videos

GM-Free Generation of Blood-Derived Neuronal Cells
08:11

GM-Free Generation of Blood-Derived Neuronal Cells

Published on: February 13, 2021

3.3K
Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

3.5K

Related Experiment Videos

Last Updated: Jan 4, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.1K
GM-Free Generation of Blood-Derived Neuronal Cells
08:11

GM-Free Generation of Blood-Derived Neuronal Cells

Published on: February 13, 2021

3.3K
Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

3.5K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Neurological diseases represent a significant global health burden with limited effective treatments.
  • Current therapeutic options for neurological disorders are insufficient, and drug approval rates are low.
  • Stem cell therapy presents a promising avenue, but requires further scientific and clinical validation.

Purpose of the Study:

  • To provide an overview of stem cell applications in neurological disease.
  • To describe the current clinical trial landscape and progress over the past decade.
  • To highlight the potential and challenges of stem cell-based therapies for neurological conditions.

Main Methods:

  • Review of stem cell types used in neurological disease treatment (neural, hematopoietic, mesenchymal, ESCs, iPSCs).
  • Analysis of the clinical trial landscape for stem cell therapies in neurological disorders.
  • Identification of neurological indications currently in clinical development.

Main Results:

  • Over 200 clinical studies involving stem cell therapy for neurological diseases are registered.
  • Multiple sclerosis, stroke, and spinal cord injuries are the most common indications in clinical trials.
  • Seventeen neurological indications are in clinical development, but few have reached pivotal randomized trial stages.

Conclusions:

  • Stem cell therapy holds promise for treating neurological diseases, but requires further evidence-based validation.
  • The majority of registered clinical studies are in early phases, with limited progression to large-scale pivotal trials.
  • Future research and robust clinical trial data are essential for the mainstream application of stem cell therapies in neurology.