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Fever-Associated Supraventricular Tachycardia after 4CMenB Vaccination in an Infant

Erdem Gönüllü1, Burcu Topçu1, Naci Öner2

  • 1Memorial Ataşehir Hospital, Department of Pediatrics, 34758 Istanbul, Turkey.

Case Reports in Pediatrics
|October 31, 2019
PubMed

Insights

The four-component meningococcal serogroup B vaccine (4CMenB) was administered to a girl who developed supraventricular tachycardia (SVT). This is the first reported case of SVT following 4CMenB vaccination.

Area of Science:

  • Vaccinology
  • Pediatric Cardiology
  • Infectious Diseases

Background:

  • Meningococcal serogroup B infections pose a significant public health risk.
  • The four-component meningococcal serogroup B vaccine (4CMenB, Bexsero) is a novel protein-based vaccine designed to prevent Neisseria meningitidis serogroup B infections.

Observation:

  • A case report details a young girl who experienced fever and supraventricular tachycardia (SVT) 6-8 hours post-second dose of the 4CMenB vaccine.
  • The SVT episode required multiple doses of adenosine for termination.

Findings:

  • This case represents the first documented instance of ECG-proven SVT occurring after 4CMenB vaccination.
  • The patient remained SVT-free during a three-month follow-up period.

Implications:

  • Healthcare providers should consider SVT in the differential diagnosis of persistent tachycardia following 4CMenB vaccination, even in the presence of fever.
  • This case highlights a potential, albeit rare, adverse event associated with meningococcal serogroup B vaccination, necessitating further surveillance and research.

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