PDE4B gene polymorphism in Russian patients with panic disorder.
Alena V Malakhova1, Olga I Rudko1, Vladimir V Sobolev2,3,4
1Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
AIMS Genetics
|October 31, 2019
Summary
Two specific PDE4B gene complex genotypes show a protective association with panic disorder, suggesting a role in mitigating genetic predisposition to the condition.
Area of Science:
- Genetics
- Psychiatry
- Molecular Biology
Background:
- Panic disorder has a complex etiology with a known genetic component.
- The PDE4B gene regulates cyclic adenosine monophosphate (cAMP) levels, impacting cellular processes.
- PDE4B gene polymorphisms have been linked to various mental health disorders, including panic disorder.
Purpose of the Study:
- To investigate the association between three single nucleotide polymorphisms (SNPs) in the PDE4B gene and the development of panic disorder.
- To evaluate the role of PDE4B gene variations in panic disorder susceptibility.
Main Methods:
- Study included 94 patients diagnosed with panic disorder (DSM-IV criteria) and 192 healthy controls.
- Genotyping of PDE4B gene SNPs was performed using real-time polymerase chain reaction (PCR) with TaqMan probes.
Main Results:
- No significant association was found between individual PDE4B SNPs and panic disorder in the general or sex-specific cohorts.
- Two complex genotypes (combinations of SNPs) in the PDE4B gene demonstrated a protective association with panic disorder, irrespective of gender.
- These protective genotypes did not show correlation with patient sex.
Conclusions:
- Two complex genotypes within the PDE4B gene are associated with a reduced risk of panic disorder.
- This suggests that PDE4B gene polymorphisms may modulate the effect of other predisposing genes in panic disorder development.
- Further research is warranted to elucidate the precise mechanisms underlying this protective effect.
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