Related Experiment Video
Updated: Jan 4, 2026

Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Gabapentin affects the expression of inflammatory mediators on healthy gingival cells
Valentina Candotto1, Luca Scapoli2, Rosa Maria Gaudio3
1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Abstract:
Gabapentin is one of the most used drugs to treat postoperative pain with antihyperalgesic properties and has a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that the perioperative use of gabapentin reduces postoperative pain. In our study, fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied, only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). The overexpression of these cytokines, obtained in many studies, leads us to think that gabapentin can interact and cause post-inflammatory gingival hyperplasia, but, probably, in our study the gabapentin has not the same effect, because we used gingival fibroblasts of healthy people.
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
GPCRs Regulate Adenylyl Cylase Activity
G-Protein Gated Ion Channels
Sensory...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...

