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Updated: Jan 4, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
14.1K
A Paradigm Shift in the Development of Anti-Candida Drugs
D V Gowda1, M Afrasim2, S I Meenakshi3
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015, India.
Current Topics in Medicinal Chemistry
|October 31, 2019
Summary
Rising Candida infections and antifungal resistance necessitate novel treatments. This review highlights natural products, combinational therapies, and immunotherapies as promising strategies to combat candidiasis effectively.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pharmacology
Background:
- Increasing incidence of Candida infections globally.
- Development of antifungal resistance due to widespread use of existing agents.
- Urgent need for novel antifungal therapies to improve patient outcomes.
Purpose of the Study:
- To review the epidemiology and types of Candidiasis.
- To describe antifungal mechanisms of action and resistance.
- To explore current and novel therapeutic approaches for Candidiasis.
Main Methods:
- Comprehensive literature search of 135 peer-reviewed studies.
- Analysis and synthesis of findings related to Candidiasis.
- Compilation of major research outcomes on antifungal strategies.
Main Results:
- Antifungal resistance is a significant concern in managing Candida infections.
- Natural plant extracts and essential oils show potential as new therapeutic sources.
- Novel strategies include combinational therapy, new antibodies, and photodynamic therapy.
Conclusions:
- Candidiasis presents significant challenges requiring innovative treatment strategies.
- Emerging approaches focus on immunotherapy, including adaptive transfer of primed immune cells and vaccine development.
- A multi-faceted approach combining natural products with advanced therapies is crucial for future treatment.
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