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Updated: Jan 4, 2026
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
A Paradigm Shift in the Development of Anti-Candida Drugs
D V Gowda1, M Afrasim2, S I Meenakshi3
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015, India.
Background:
The considerable increase in the incidence of Candida infection in recent times has prompted the use of numerous antifungal agents, which has resulted in the development of resistance towards various antifungal agents. With rising Candida infections, the need for design and development of novel antifungal agents is in great demand. However, new therapeutic approaches are very essential in preventing the mortality rate and improving the patient outcome in those suffering from Candida infections.
Objective:
The present review objective is to describe the burden, types of Candidiasis, mechanism of action of antifungal agents and its resistance and the current novel approaches used to combat candidiasis.
Methods:
We have collected and analyzed 135 different peer-reviewed literature studies pertinent to candidiasis. In this review, we have compiled the major findings from these studies.
Results And Conclusion:
The review describes the concerns related to candidiasis, its current treatment strategy, resistance mechanisms and imminent ways to tackle the problem. The review explored that natural plant extracts and essential oils could act as sources of newer therapeutic agents, however, the focus was on novel strategies, such as combinational therapy, new antibodies, utilization of photodynamic therapy and adaptive transfer primed immune cells with emphasis on the development of effective vaccination.
Insights
Rising Candida infections and antifungal resistance necessitate novel treatments. This review highlights natural products, combinational therapies, and immunotherapies as promising strategies to combat candidiasis effectively.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pharmacology
Background:
- Increasing incidence of Candida infections globally.
- Development of antifungal resistance due to widespread use of existing agents.
- Urgent need for novel antifungal therapies to improve patient outcomes.
Purpose of the Study:
- To review the epidemiology and types of Candidiasis.
- To describe antifungal mechanisms of action and resistance.
- To explore current and novel therapeutic approaches for Candidiasis.
Main Methods:
- Comprehensive literature search of 135 peer-reviewed studies.
- Analysis and synthesis of findings related to Candidiasis.
- Compilation of major research outcomes on antifungal strategies.
Main Results:
- Antifungal resistance is a significant concern in managing Candida infections.
- Natural plant extracts and essential oils show potential as new therapeutic sources.
- Novel strategies include combinational therapy, new antibodies, and photodynamic therapy.
Conclusions:
- Candidiasis presents significant challenges requiring innovative treatment strategies.
- Emerging approaches focus on immunotherapy, including adaptive transfer of primed immune cells and vaccine development.
- A multi-faceted approach combining natural products with advanced therapies is crucial for future treatment.
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